Author

Jiayi Dong

Boston Children's HospitalORCID 0000-0003-4028-1057Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Alexandre AlbaneseiD· 1 shared Andrea GarmillaiD· 1 shared Ariana E. Barreiro· 1 shared Birkley S. LimiD· 1 shared Blake E. SmithiD· 1 shared Bruce R. BlazariD· 1 shared Caleb R. PereziD· 1 shared Connor S. DobsoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alexandre AlbaneseORCID

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2 papers

Recent·Most cited

ImmunologyBlood Immunology & Cellular TherapyPeer-reviewedApr 20, 2026

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

Holly Wobma, Francesca Alvarez Calderon, Jiayi Dong…·Leslie S. Kean

This study edits Cyclophilin A's C-terminus using CRISPR/Cas9 to create cell therapies resistant to cyclosporine and voclosporin, preserving function in immune suppression settings.

DOI 10.1016/j.bict.2026.100054

mousegenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologyScience AdvancesPeer-reviewedNov 7, 2025

Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells

Ellen J.K. Xu, Blake E. Smith, Winiffer D. Conce Alberto…·Michael E. Birnbaum

This study develops pMHC-targeted retroviruses for in vivo gene delivery to tumor-specific T cells, enhancing their expansion and anti-tumor activity in mouse models.

5 citations

mouseCITE-seq

𝕏 PostBluesky