Author

Alexander M. Bergendorf

Case Western Reserve UniversityORCID 0009-0007-2424-8448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

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Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brendan K. BalliD· 2 shared Douglas K. BrubakeriD· 2 shared Jee Hyun ParkiD· 2 shared Elizabeth A. ProctoriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersSystems Biology

Brendan K. BallORCID

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2 papers

Recent·Most cited

Systems Biologynpj Systems Biology and ApplicationsPeer-reviewedJul 3, 2026

Mouse-to-human modeling of microglia single-nuclei transcriptomics identifies immune signaling pathways and potential therapeutic candidates associated with Alzheimer's disease

Alexander M. Bergendorf, Jee Hyun Park, Brendan K. Ball, Douglas K. Brubaker

The paper integrates mouse and human microglia transcriptomics to identify AD-related pathways and drugs using TransComp-R, finding FDA-approved drugs that mimic healthy human microglia in mice.

DOI 10.1038/s41540-026-00775-3

mousehuman

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Systems Biologynpj Systems Biology and ApplicationsPeer-reviewedMay 29, 2025

Cross-disease modeling of peripheral blood identifies biomarkers of type 2 diabetes predictive of Alzheimer's disease

Brendan K. Ball, Jee Hyun Park, Alexander M. Bergendorf…·Douglas K. Brubaker

This paper uses cross-disease modeling to identify T2D biomarkers predictive of Alzheimer's disease and suggests a T2D medication that may prevent AD onset.

12 citationstop 2%

humanbulk RNA-seq

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