Elizabeth A. Proctor

PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation

This study shows PD-1 in CD4+ T cells balances antiviral defense and neuroinflammation during polyomavirus CNS infection by modulating CD8+ T cell responses.

Metabolites associated with type 2 diabetes and Alzheimer's disease trigger differential intracellular signaling responses in mouse primary neurons

The paper investigates how metabolites linked to type 2 diabetes and Alzheimer's disease affect intracellular signaling in mouse neurons, identifying specific pathway activations associated with disease progression or protection.

Cross-disease modeling of peripheral blood identifies biomarkers of type 2 diabetes predictive of Alzheimer's disease

This paper uses cross-disease modeling to identify T2D biomarkers predictive of Alzheimer's disease and suggests a T2D medication that may prevent AD onset.

Comprehensive mapping of the Interaction of levodopa and iron metabolism in Parkinson's disease

This paper uses deep machine learning to identify molecular mechanisms by which levodopa affects iron metabolism in Parkinson's disease, revealing interactions with iron transporters and pathways.

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites

The paper investigates how primary neurons respond to metabolites linked to type 2 diabetes and Alzheimer's disease, identifying differential secretion of MCP-1 and IL-9.

MODERATE ALCOHOL CONSUMPTION INDUCES LASTING IMPACTS ON PREFRONTAL CORTICAL SIGNALING IN MICE

This study shows that moderate alcohol consumption in mice affects prefrontal cortical signaling and neuronal excitability, potentially influencing Alzheimer's disease progression.

Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer's disease

The paper identifies immune signatures predicting changes in neural circuit activity in a mouse Alzheimer's model.

Dynamic neuroinflammatory profiles predict Alzheimer's disease pathology in microglia-containing cerebral organoids

This study uses AD organoids to identify dynamic neuroinflammatory profiles and their impact on neuronal health and microglial function.

Alzheimer's disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism

This study identifies an Alzheimer's disease-specific cytokine signature that suppresses mitochondrial function in neurons, linking neuroinflammation to metabolic dysfunction.

Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-β

This study shows that APOE4 astrocytes increase neuronal metabolic stress in the presence of amyloid-β compared to APOE3 astrocytes.

Neurovascular coupling and bilateral connectivity during NREM and REM sleep

This study examines how cerebral hemodynamics change during different sleep states in mice, finding that hemodynamic responses during NREM and REM sleep are significantly larger than those evoked by sensory stimulation.

Novel microRNA multivariate biomarkers of response to immunotherapy against HPV E6 oncogene

The paper identifies miR signatures modulated by anti-HPV E6 mAbs that predict response to treatment in cervical cancer models.

A framework for translation of genomic responses from mouse models to human inflammatory disease contexts

This paper develops a semi-supervised learning framework to translate genomic responses from mouse models to human inflammatory disease contexts, finding it more accurate than direct generalization.