Early AMPA receptor potentiation modifies synaptic maturation and disease progression in Rett models
Giuseppina De Rocco, Andrea de Donato, Marzia Tina Indrigo, Virginia Varotto, Martina Geusa, Stefano Taverna, Ingrid Cifola, Eva Pinatel, Angelisa Frasca, Nicoletta Landsberger
This study evaluates the effects of early AMPA receptor potentiation in Rett syndrome models, finding that early treatment improves survival, motor function, and cognition, while later treatment is less effective.
bioRxiv · Aug 7, 2026 · PreprintNeuroscience