Angelisa Frasca

This study shows that deleting Cit-k in oligodendroglia causes hypomyelination and cognitive deficits in mice, independent of neuronal defects.

This study evaluates the effects of early AMPA receptor potentiation in Rett syndrome models, finding that early treatment improves survival, motor function, and cognition, while later treatment is less effective.

Mecp2 knock-out mouse astrocytes accumulate cholesterol yet release poorly lipidated ApoE; cholesterol supplementation restores synaptic puncta density in neurons exposed to their conditioned medium and in Mecp2 heterozygous neurons.

This study shows that neural precursor cell transplantation improves symptoms of Rett syndrome by activating the Interferon γ pathway.

This study shows that Mecp2 knock-out astrocytes reduce synaptic density by secreting IL-6, which can be mitigated by blocking IL-6 activity.