Giuseppina De Rocco

Early AMPA receptor potentiation modifies synaptic maturation and disease progression in Rett models

This study evaluates the effects of early AMPA receptor potentiation in Rett syndrome models, finding that early treatment improves survival, motor function, and cognition, while later treatment is less effective.

Spatially resolved mapping of histones reveal selective neuronal response in Rett syndrome

This study uses mass spectrometry imaging and laser capture microdissection to analyze histone proteoforms in RTT mouse models, revealing neuron-specific differences and mutation-dependent chromatin changes.

The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes

This study shows that enhancing neuronal activity rescues developmental defects in Mecp2 null neurons, improving their maturation and extending lifespan in a mouse model of Rett syndrome.