Nicoletta Landsberger

This study evaluates the effects of early AMPA receptor potentiation in Rett syndrome models, finding that early treatment improves survival, motor function, and cognition, while later treatment is less effective.

Mecp2 knock-out mouse astrocytes accumulate cholesterol yet release poorly lipidated ApoE; cholesterol supplementation restores synaptic puncta density in neurons exposed to their conditioned medium and in Mecp2 heterozygous neurons.

This study uses mass spectrometry imaging and laser capture microdissection to analyze histone proteoforms in RTT mouse models, revealing neuron-specific differences and mutation-dependent chromatin changes.

This study shows that neural precursor cell transplantation improves symptoms of Rett syndrome by activating the Interferon γ pathway.

This study shows that Mecp2 knock-out astrocytes reduce synaptic density by secreting IL-6, which can be mitigated by blocking IL-6 activity.

This study shows that enhancing neuronal activity rescues developmental defects in Mecp2 null neurons, improving their maturation and extending lifespan in a mouse model of Rett syndrome.