NeuroscienceeLifePeer-reviewed
DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response
Ernie Yulyaningsih, Jung H. Suh, Melania H. Fanok…·Pascal E. Sanchez
DNL343 reduces neurodegeneration in mouse models by inhibiting the integrated stress response and normalizing dysregulated biomarkers, with potential clinical relevance for vanishing white matter disease.
11 citations