BiophysicsbioRxivPreprint
Desmoglein-2 deficiency results in cardiac dysfunction by compromising both Z-disc- and intercalated disc-mediated mechanotransduction
Maicon Landim-Vieira, Vivek Jani, Emily Shiel…·Stephen P. Chelko
This study shows that DSG2 deficiency causes cardiac dysfunction by impairing Z-disc and intercalated disc mechanotransduction, leading to structural and functional cardiac defects.
DOI 10.1101/2025.10.03.680335