MicrobiologybioRxivPreprint
CRISPR-Cas interference decays rapidly with distance from the leader sequence in a long array
Marijn Ceelen, Mauro Albertini, Gregory J. Velicer, Sébastien Wielgoss
The paper shows that CRISPR-Cas interference in Myxococcus xanthus declines rapidly with distance from the leader sequence, with only ~4% of spacers effective, contrasting with ~95% effectiveness in Vibrio cholerae.
DOI 10.64898/2026.07.09.737519