BiochemistryJournal of Medicinal ChemistryPeer-reviewed
ByeTAC: Bypassing an E3 Ligase for Targeted Protein Degradation
Cody A. Loy, Eslam M.H. Ali, Laurence J. Seabrook…·Darci Jones Trader
This paper introduces ByeTACs, bifunctional degraders that target proteins by interacting with the 26S proteasome instead of an E3 ligase, and shows they effectively degrade BRD4.
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