Author

Laurence J. Seabrook

University of California SystemORCID 0000-0002-9337-9712Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Cody A. LoyiD· 1 shared Darci Jones TraderiD· 1 shared Eslam M.H. AliiD· 1 shared Kate A. Kragness· 1 shared Lauren Veronica AlbrechtiD· 1 shared Timothy J. HarrisiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

Cody A. LoyORCID

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1 paper

Recent·Most cited

BiochemistryJournal of Medicinal ChemistryPeer-reviewedApr 19, 2025

ByeTAC: Bypassing an E3 Ligase for Targeted Protein Degradation

Cody A. Loy, Eslam M.H. Ali, Laurence J. Seabrook…·Darci Jones Trader

This paper introduces ByeTACs, bifunctional degraders that target proteins by interacting with the 26S proteasome instead of an E3 ligase, and shows they effectively degrade BRD4.

43 citationstop 1%

experimental assaydrug response / drug discovery

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