Author

Lauren Veronica Albrecht

University of California, IrvineORCID 0000-0002-3147-8010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alijah Macapagal· 1 shared Angela Lackner· 1 shared Hal M. HoffmaniD· 1 shared Hannah J. LeeiD· 1 shared Huilin XuiD· 1 shared Janset OnyuruiD· 1 shared Julia Elise CabraliD· 1 shared Karen Wang· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alijah Macapagal

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1 paper

Recent·Most cited

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

Angela Lackner, Sofia I. Picucci, Wenjin Jiang, Janset Onyuru, Melissa Campos, Julia Elise Cabral, Lemuel Leonidas, Alijah Macapagal, Hannah J. Lee, Valerie Henriquez, Karen Wang, Huilin Xu, Yanfei Qiu, Lauren Veronica Albrecht, Hal M. Hoffman, Reginald McNulty

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

Communications Biology · Apr 16, 2026Peer-reviewedImmunology