Author

Darren Darren

National University of SingaporeORCID 0009-0007-7012-3486Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

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Alena KroupovaiD· 1 shared Alessio CiulliiD· 1 shared Andre J. WijayaiD· 1 shared David ZollmaniD· 1 shared Denzel Gonzales· 1 shared Dylan M. LynchiD· 1 shared Hirotake FurihataiD· 1 shared Julie Pethe· 1 shared

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1 shared paperBiochemistry

Alena KroupovaORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedOct 15, 2024

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter…·Alessio Ciulli

The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.

53 citationstop 2%

protein structureexperimental assay

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