Author

Valentina A. Spiteri

University of DundeeORCID 0000-0002-5002-4989Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro Correa-SáeziD· 1 shared Alessio CiulliiD· 1 shared Angus D. CowaniD· 1 shared Caroline SchätziD· 1 shared Dmitri SegaliD· 1 shared Gajanan J. SatheiD· 1 shared Georg E. WinteriD· 1 shared Hannah E. Peters· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Alejandro Correa-SáezORCID

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1 paper

Recent·Most cited

Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4

Valentina A. Spiteri, Dmitri Segal, Alejandro Correa-Sáez, Kentaro Iso, Ryan Casement, Miquel Muñoz i Ordoño, Mark A. Nakasone, Gajanan J. Sathe, Caroline Schätz, Hannah E. Peters, Mark Dorward, Lisa Kainacher, Angus D. Cowan, Alessio Ciulli, Georg E. Winter

This study shows that a monovalent MGD can recruit two E3 ligases redundantly to degrade SMARCA2/4, with tunable ligase preference through chemical and genetic modifications.

bioRxiv · Aug 4, 2025 · PreprintBiochemistry