James Lancaster

This study uses single-cell multi-omics to compare immune cell landscapes and vaccine responses in SAD and CVID patients, identifying unique cellular and molecular features associated with poor vaccination responses.

The paper uses single-cell CRISPR activation screens in human B cells to link non-coding autoimmune risk loci to their cis-regulatory target genes, revealing shared genetic mechanisms across diseases.

LongBench benchmarks long-read RNA-sequencing technologies using a cross-platform dataset of cancer cell lines, showing high gene-level concordance but reduced transcript-level consistency across platforms.

This paper develops D4Z4End2End, a workflow using long-read sequencing to characterize D4Z4 macrosatellite genetics and methylation in FSHD, BAMS, and reference cohorts, revealing new variants and methylation patterns.

This study evaluates long-read de novo transcriptome assembly tools for differential expression analysis without a reference genome, finding RNA-Bloom2 with Corset as the most accurate and efficient.

This study uses adaptive nanopore sequencing to measure X inactivation skew in carrier females with X-linked retinal diseases, showing a strong correlation between skew and disease presentation.