Davide Maria Vespasiani

This study uses single-cell multi-omics to compare immune cell landscapes and vaccine responses in SAD and CVID patients, identifying unique cellular and molecular features associated with poor vaccination responses.

The paper investigates the regulatory effects of Neanderthal and Denisovan introgression in Papuan populations using a massively parallel reporter assay, finding differential activity in immune-related genes.

The paper uses single-cell CRISPR activation screens in human B cells to link non-coding autoimmune risk loci to their cis-regulatory target genes, revealing shared genetic mechanisms across diseases.

This study identifies ZFP36L1 and ZFP36L2 as RNA-binding proteins that regulate the G2-M checkpoint in GC B cells to prevent replication stress and maintain genome stability.

The paper identifies dunnart-specific enhancers and promoters in craniofacial development, showing divergence in regulatory landscapes between marsupials and placental mammals.

The paper tests regulatory potential of conserved enhancers in thylacine and wolf to assess functional convergence over 160 million years of evolution, finding limited evidence of convergent divergence.

The paper identifies Denisovan introgression in Papuan genomes that influences immune-related processes and regulatory elements, with experimental validation of functional impacts.