Minggao He

ClairS is a deep-learning method for long-read somatic variant calling that outperforms existing tools on synthetic and short-read datasets.

The paper re-architected a variant caller into a client-server system to improve agent-driven variant calling efficiency and reliability.

Clair3 v2 improves variant calling accuracy for Oxford Nanopore Technologies sequencing by using move table data and dwelling time, achieving higher F1-scores for SNPs and Indels.

Clair-Mosaic detects mosaic small variants from long-read sequencing data using deep learning, achieving high sensitivity and accuracy in both paired and single-sample modes.