Author

Dale Handley

Brunel University of LondonORCID 0009-0008-0944-1634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexandra C. GillettiD· 1 shared Alexandra I. F. BlakemoreiD· 1 shared Andrianos M. Yiorkas· 1 shared Carel Wynand le RouxiD· 1 shared Cathryn M. LewisiD· 1 shared Chris Wai Hang LoiD· 1 shared Fotios DrenosiD· 1 shared Francesco CasanovaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexandra C. GillettORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintMar 17, 2026

Clustering of major depressive disorder genetic instruments identifies distinct and directionally opposing effects on cardiometabolic risk

Dale Handley, Renu Bala, Francesco Casanova…·Jessica Tyrrell

This study uses MR-Clust to identify three MDD genetic clusters with opposing effects on T2D and cardiometabolic risk, linking them to distinct biological pathways and depression subtypes.

DOI 10.64898/2026.03.16.26347391

humanGWAS summary statistics

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Genetic & Genomic MedicinemedRxivPreprintAug 4, 2023

Severe obesity may be an oligogenic condition: evidence from 1,714 adults seeking treatment in the UK National Health Service

Sumaya Almansoori, Hasnat A Amin, Suzanne Alsters…·Alexandra I. F. Blakemore

This study identifies rare genetic variants in obesity-related genes in a UK cohort of severe obesity patients, suggesting an oligogenic inheritance pattern and demonstrating the utility of custom genotyping arrays.

DOI 10.1101/2023.08.04.23293229

humanwhole-exome sequencing

𝕏 PostBluesky