The paper shows ethanol stress causes vacuole unlobing via Fab1-mediated phosphatidylinositol-3,5-bisphosphate regulation, essential for ethanol tolerance.

DOI 10.1016/j.ejcb.2026.151548

imagingexperimental assay

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Cell BiologyCell Death DiscoveryPeer-reviewedJun 5, 2026

Novel truncating Desmin mutation Arg150Stop disrupts structural integrity and cellular homeostasis by formation of persistent aggregate-like structure

Sukanya Mitra, Trisha Ghosh, Arun Kumar Mishra…·Moulinath Acharya

This study investigates a novel truncating Desmin mutation, Arg150Stop, showing it causes persistent aggregate-like structures that disrupt cellular homeostasis and cytoskeletal integrity through a toxic gain-of-function mechanism.

DOI 10.1038/s41420-026-03184-x

humanproteomics

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Cell BiologyFEBS LettersPeer-reviewedNov 17, 2025

Two paralogues of N-ethylmaleimide sensitive factor: An exception to the minimal vesicular trafficking machinery of Giardia

Trisha Ghosh, Nibedita Ray Chaudhuri, Shankari Prasad Datta…·Srimonti Sarkar

The paper identifies two paralogues of NSF in Giardia, showing distinct localization and potential non-canonical functions in flagellar motility and stress adaptation.

DOI 10.1002/1873-3468.70225

humanexperimental assay

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Cell BiologyPLoS neglected tropical diseasesPeer-reviewedNov 12, 2025

Divergent Functions of Late ESCRT Components in Giardia lamblia: Insights from Subcellular Distributions and Protein Interactions

Nabanita Patra, Nabanita Saha, Trisha Ghosh…·Srimonti Sarkar

This study investigates the subcellular distribution and interactions of late ESCRT paralogs in Giardia lamblia, revealing distinct functions and potential roles in encystation.

1 citation

humanproteomics

𝕏 PostBluesky