Author

Paula Armina V. Buco

The University of MelbourneORCID 0009-0008-3451-4188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alistair Morgan ChalkiD· 2 shared Carl R. WalkleyiD· 2 shared Monique F. M. A. SmeetsiD· 2 shared Wilson Castillo‐TandazoiD· 2 shared Amnon KoreniD· 1 shared Ashfaqul HoqueiD· 1 shared Courtney PilcheriD· 1 shared Jessica K. HolieniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCell Biology

Alistair Morgan ChalkORCID

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2 papers

Recent·Most cited

Cell BiologyEMBO ReportsPeer-reviewedMar 10, 2026

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication.

Paula Armina V. Buco, Wilson Castillo‐Tandazo, Alistair Morgan Chalk…·Carl R. Walkley

This study identifies KLHDC3 as a rescue factor for RECQL4 mutations, showing that low levels of a truncated RECQL4 protein can support DNA replication without requiring its ATPase or helicase domains.

3 citations

mouseexperimental assay

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Developmental BiologybioRxivPreprintAug 5, 2025

Deletion of KLHDC3, an E3 ubiquitin ligase complex substrate receptor, leads to obesity in mice.

Paula Armina V. Buco, Ashfaqul Hoque, Wilson Castillo‐Tandazo…·Carl R. Walkley

This study shows that deleting Klhdc3 in mice causes obesity and developmental issues, highlighting its role in regulating protein stability and adiposity.

DOI 10.1101/2025.08.05.668783

mouseproteomics

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