Author

Obsa Seid

University of WashingtonORCID 0009-0008-4348-1082Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Airi HosokaiiD· 2 shared Andrew B. StergachisiD· 2 shared Cameron WenmaniD· 2 shared Douglas M. FowleriD· 2 shared Ivan M. H. WooiD· 2 shared Lara A. MuffleyiD· 2 shared Lea M. StaritaiD· 2 shared Leslie Rodriguez-SalasiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Airi HosokaiORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintJun 13, 2026

Saturation Genome Editing reveals the functional impact of RAD51D and XRCC2 variants

Silvia Casadei, Matthew W. Snyder, Ivan M. H. Woo…·Lea M. Starita

The paper uses saturation genome editing to assess the functional impact of RAD51D and XRCC2 variants, showing high accuracy in distinguishing pathogenic from benign variants.

DOI 10.64898/2026.06.12.731983

humanwhole-exome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 23, 2026

A scalable approach to resolving variants of uncertain significance

Malvika Tejura, Y P Chen, Abbye E. McEwen…·Lea M. Starita

The paper develops a scalable workflow to reclassify variants of uncertain significance using experimental and predictive evidence, resolving 75% of VUS in 40 genes.

4 citations

humanwhole-exome sequencing

𝕏 PostBluesky