Author

Odilia Sianto

Stanford Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Aaron D. GitleriD· 5 shared Tetsuya AkiyamaiD· 5 shared Yi ZengiD· 4 shared Caiwei GuoiD· 3 shared Chang LiuiD· 3 shared Leonard PetrucelliiD· 3 shared Anastasiia LovchykovaiD· 2 shared Juliane Bombosch· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersNeuroscience

Aaron D. GitlerORCID

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5 papers

Recent·Most cited

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

Caiwei Guo, Kuchuan Chen, Sarat C. Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell, Shannon Zhen, Shila Mekhoubad, Ryan D. Morrie, Georgiana Miller, Dragana Ilic, , Aaron D. Gitler

This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.

Science Translational Medicine · Jun 3, 2026Peer-reviewedNeuroscience

Whole-genome 3D architectural screen reveals modulators of brain DNA structure

Bibudha Parasar, Achuthan Raja Venkatesh, Jonathan Perera, Lucas Sosnick, Siavash Moghadami, Yunji Seo, Jenny Shi, Lynette Chan, Satoshi Takenawa, Tetsuya Akiyama, Odilia Sianto, Takeshi Uenaka, Angela G. Hadjipanayis, Marius Wernig, Aaron D. Gitler, Longzhi Tan

The paper introduces Plate-C, a high-throughput method for whole-genome 3D architecture profiling, and identifies modulators of DNA structure across multiple biological pathways and cell types.

bioRxiv · Apr 17, 2026 · PreprintGenomics

KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS

Tetsuya Akiyama, Yi Zeng, Caiwei Guo, Olivia Gautier, Lauren S. Koepke, Heankel Lyons, Elana Molotsky, Juliane Bombosch, Odilia Sianto, Jay P. Ross, Phuong T. Hoang, Luke Zhao, Cole Spencer, Charlotte J. Sumner, Michelle Monje, , Aaron D. Gitler

This study shows that SMN deficiency reduces KIF5A in SMA, impairing axon regeneration, and links SMA and ALS through KIF5A stabilization by SMN.

JCI Insight · Mar 26, 2026Peer-reviewedNeuroscience

Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss

Yi Zeng, Odilia Sianto, Anastasiia Lovchykova, Chang Liu, Tetsuya Akiyama, Leonard Petrucelli, Aaron D. Gitler

The paper shows that TDP-43 loss causes cryptic splicing events that are masked by nonsense-mediated decay, and inhibiting this decay reveals hundreds of novel splicing events.

bioRxiv · Jul 9, 2025 · PreprintNeuroscience

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes

Yi Zeng, Anastasiia Lovchykova, Tetsuya Akiyama, Chang Liu, Caiwei Guo, Vidhya Maheswari Jawahar, Odilia Sianto, Anna Calliari, Mercedes Prudencio, Dennis W. Dickson, Leonard Petrucelli, Aaron D. Gitler

This study shows that TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes affecting disease-relevant genes.

bioRxiv · Jan 22, 2024 · PreprintNeuroscience