Author

Siddarth Wekhande

Broad InstituteORCID 0009-0008-7539-8718Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alejandro CollinsiD· 1 shared Anna J. CruziD· 1 shared B BernsteiniD· 1 shared Charles B. EpsteiniD· 1 shared Eugenio MatteiiD· 1 shared Fadi J. NajmiD· 1 shared Jason Daniel BuenrostroiD· 1 shared John G. DoenchiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Alejandro CollinsORCID

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1 paper

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedFeb 4, 2025

Multi-locus CRISPRi targeting with a single truncated guide RNA

Molly M. Moore, Siddarth Wekhande, Robbyn Issner…·Fadi J. Najm

This paper develops a CRISPRi approach using truncated guides to screen multiple transcription factor binding sites, showing they can disrupt enhancer activity and repress transcription factor binding.

6 citations

humanCRISPR screen

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