NeurosciencebioRxivPreprint
Non-neuronal, TGF-β- extracellular matrix restructuring promotes neurodegeneration in a PSP-Richardson syndrome model
Clara Zannino, Desirèe Valente, Davide Bressan…·Elvira Immacolata Parrotta
The paper identifies TGF-β-driven extracellular matrix remodeling in vascular leptomeningeal-like cells as a driver of neurodegeneration in PSP-RS, showing therapeutic potential through pharmacological inhibition.
DOI 10.1101/2025.08.17.670724