Alessandro Fiorenzano

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

This study investigates how rare genetic variants in PD patients affect mitochondrial lipid homeostasis and neuronal excitability using patient-derived dopaminergic neurons.

This study investigates how co-grafting strategies influence dopamine neuron specification and maturation in a Parkinson's disease model, identifying key transcription factors involved in the process.

This paper describes a protocol for isolating nuclei from human stem cell-derived grafts in rat brains for single-nucleus RNA sequencing.

The paper identifies TGF-β-driven extracellular matrix remodeling in vascular leptomeningeal-like cells as a driver of neurodegeneration in PSP-RS, showing therapeutic potential through pharmacological inhibition.

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

This study identifies T-UCstem1 as a key lncRNA regulating gastruloid development through DKK1-dependent modulation of WNT signaling, affecting anteroposterior axis extension and cellular identity.

The paper introduces a novel iPSC-derived mosaic midbrain organoid system to model PSP-RS and demonstrates its ability to recapitulate key pathological features of the disease.

The paper evaluates TH-Cre knock-in cell lines for identifying and isolating stem cell-derived dopaminergic neurons in vitro and in vivo.

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.

The paper uses scRNA-seq to analyze graft composition in a Parkinson’s disease cell therapy model, revealing differences between human stem cell-derived and fetal tissue grafts.