Simone Ebert

Eyewire II provides a large-scale EM dataset of the mouse retina, enabling cell type annotation and connectivity mapping through human-in-the-loop deep learning and functional alignment.

The paper shows VIP+ amacrine cells in the retina both inhibit and excite specific ganglion cells, coordinating their activity through gap junctions and GABAergic synapses.

The paper shows that two inhibitory connectivity motifs in the retina—feed-forward and recurrent feedback inhibition—produce distinct motion anticipation mechanisms with different speed-dependent response scaling.

The paper shows that depressing inhibitory synapses enable retinal ganglion cells to signal omitted stimuli in flash sequences, revealing a mechanism for predictive error signaling.