David M. Berson

Eyewire II provides a large-scale EM dataset of the mouse retina, enabling cell type annotation and connectivity mapping through human-in-the-loop deep learning and functional alignment.

The paper examines how different ON bipolar cell subtypes generate distinct kinetic responses in transient and sustained ON retinal ganglion cells through synaptic mechanisms.

This study investigates the structure and function of Muller glial sheaths in the retina's vascular layers, revealing compartmentalized interactions between glia and vessels.

The paper evaluates melanopsin reporter systems for labeling retinal ganglion cells and finds no method labels all and only intrinsic photosensitive retinal ganglion cells.

The paper identifies VGluT3 amacrine cells as a source of inhibition that limits the range of retinal slip speeds driving optokinetic responses in mice.

The paper investigates whether light affects human prefrontal cortex activity through a pathway similar to that in animals, finding luminance-dependent signals in multiple brain regions.

The paper investigates how intrinsically photosensitive retinal ganglion cells (ipRGCs) encode environmental light intensity by showing their unique synaptic drive and resistance to postsynaptic filtering.

The paper identifies glycinergic narrow field amacrine cells as a dominant inhibitory source for retinal ON starburst amacrine cells, revealing their role in modulating direction selectivity through ultra-slow glycine receptors.

The paper investigates how spatially displaced excitation influences the direction selectivity of On-Off DSGCs during interrupted motion, showing its role in encoding visual features.

The paper identifies a new inhibitory retinal amacrine cell type, MAC, that forms direct electrical and chemical synapses with Müller glia, revealing neuron-glia coupling in the mammalian retina.

This study demonstrates that acetylcholine (ACh) signaling at retinal synapses exhibits both synaptic and non-synaptic transmission characteristics, with rapid currents and limited spread.

The paper investigates the synaptic circuits in intrinsically photosensitive retinal ganglion cells (ipRGCs) that encode light intensity, showing that Type 6 ON cone bipolar cells provide the strongest luminance signal.

The paper identifies novel genes and reveals molecular diversity in mouse intrinsically photosensitive retinal ganglion cells (ipRGCs), showing unexpected complexity in their gene expression patterns.