NeurosciencebioRxivPreprint
Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimers disease
DOI 10.64898/2026.08.20.746036
Author
Mayuko Arai
Simon Fraser UniversityORCID 0009-0008-9391-4149Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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Recent·Most cited
- NeuroscienceSLEEP AdvancesPeer-reviewed
The Effects of Acute Trazodone Administration on Sleep in Mice
This study shows that trazodone increases NREM sleep and delta power in mice, replicating its effects in humans, using a novel voluntary oral administration protocol.
2 citations - NeurosciencebioRxivPreprint
Impact of Optogenetic Activation of the Thalamic Reticular Nucleus on Sleep Architecture in Mice
Mayuko Arai, Sean Tok, Brianne A. Kent
This study investigates the effect of optogenetic activation of GABAergic TRN neurons on sleep architecture in mice, finding no significant changes in sleep state durations or delta wave power.
DOI 10.1101/2024.10.04.616683