NeurosciencebioRxivPreprint
Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimers disease
DOI 10.64898/2026.08.20.746036
Author
Cheryl Lea Wellington
University of British ColumbiaORCID 0000-0001-7014-039XUnclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2022-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 33 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship8 papers
Recent·Most cited
- NeurosciencebioRxivPreprint
Repeated mild traumatic brain injury does not affect sleep or epileptiform activity one-month post-injury in a knock-in mouse model of Alzheimer's disease
Victoria Carriquiriborde, Jefferey Yue, Wai H. Cheng…·Brianne A. Kent
This study investigates the effects of repeated mild traumatic brain injury on sleep, epileptiform activity, and Alzheimer's disease pathology in a knock-in mouse model one month post-injury.
DOI 10.64898/2026.07.24.740449 - NeuroscienceJournal of NeurotraumaPeer-reviewed
Repetitive mild traumatic brain injury causes neuronal damage in the APP/PS1 mouse model of Alzheimer's disease without an enduring impact on amyloid pathology, sleep, or epileptiform activity
Jefferey Yue, Victoria Carriquiriborde, Wai Hang Cheng…·Brianne A. Kent
- NeurosciencebioRxivPreprint
Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain.
Sofia Kakava, Mary Gonzalez Melo, Wai Hang Cheng…·Jérôme Robert
The paper investigates how high-density lipoproteins (HDL) cross the blood-brain barrier, showing that LDLR and apoE composition determine HDL entry and brain localization.
DOI 10.1101/2025.05.23.655828 - NeurosciencebioRxivPreprint
Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries
Marangelie Criado‐Marrero, Sakthivel Ravi, Ekta Bhaskar…·Jose Francisco Abisambra
This study examines how age affects brain connectivity and white matter integrity after repetitive mild traumatic brain injuries in mice using multimodal imaging techniques.
- NeurosciencebioRxivPreprint
Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury
Ilaria Lisi, Federico Moro, Edoardo Mazzone…·the InTBIR Fundamental & Translational Working Group
This study reviews preclinical blood biomarkers for traumatic brain injury, finding that NfL and GFAP show promise for prognosis and pharmacodynamic studies.
DOI 10.1101/2023.12.01.569152 - NeurosciencebioRxivPreprint
Leveraging the power of 3D brain-wide imaging and mapping tools for brain injury research in murine models
Mehwish Anwer, Jeffrey M. LeDue, Zefang Wang…·Cheryl Lea Wellington
The paper describes a whole-brain imaging pipeline to study neuronal activity changes after traumatic brain injury in mice, finding reduced c-Fos cell density in injured brains.
- NeurosciencebioRxivPreprint
Altered tau in rTg4510 mice after a single interfaced CHIMERA traumatic brain injury
Wai Hang Cheng, Honor Cheung, Amy Kang…·Cheryl Lea Wellington
This study examines the effects of a single moderate-severe TBI in rTg4510 mice using CHIMERA, finding divergent tauopathy and autophagolysosome responses in surviving mice.
DOI 10.1101/2022.09.01.506145