Author

David Driscoll

Howard Hughes Medical InstituteORCID 0009-0009-0395-7573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Jeff GellesiD· 1 shared Larry J. FriedmaniD· 1 shared Stephen P. BelliD· 1 shared

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2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Jeff GellesORCID

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1 paper

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedOct 7, 2025

An Orc6 tether mediates ORC binding site switching during replication origin licensing

David Driscoll, Larry J. Friedman, Jeff Gelles, Stephen P. Bell

This paper identifies an Orc6 tethering interaction that enables ORC to switch binding sites during replication origin licensing, showing its role in helicase loading and cell-cycle regulation.

3 citations

proteomicsexperimental assay

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