Cancer BiologyFrontiers in Drug DiscoveryPeer-reviewed
Dual RNA Polymerase I Inhibition with CX-5461 and BMH-21 Synergizes in Breast Cancer by Activating p53-Dependent Stress
JH Chung, Kristen N. Nguyen, Bruce A. Knutson
This study shows that combining CX-5461 and BMH-21, two Pol I inhibitors, synergizes to inhibit cancer cell growth by enhancing Pol I inhibition and p53 activation.
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