Author

Bruce A. Knutson

SUNY Upstate Medical UniversityORCID 0000-0003-3599-1302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:yeast· 1

Frequent Co-Authors

JH ChungiD· 1 shared Katrina N. Rothblum· 1 shared Kristen N. Nguyen· 1 shared Lawrence Ian RothblumiD· 1 shared Rachel McNamariD· 1 shared Zakaria Abu-Adas· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperCancer Biology

JH ChungORCID

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2 papers

Recent·Most cited

Cancer BiologyFrontiers in Drug DiscoveryPeer-reviewedJan 5, 2026

Dual RNA Polymerase I Inhibition with CX-5461 and BMH-21 Synergizes in Breast Cancer by Activating p53-Dependent Stress

JH Chung, Kristen N. Nguyen, Bruce A. Knutson

This study shows that combining CX-5461 and BMH-21, two Pol I inhibitors, synergizes to inhibit cancer cell growth by enhancing Pol I inhibition and p53 activation.

1 citation

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyJournal of Biological ChemistryPeer-reviewedNov 14, 2019

Inducible degron-dependent depletion of the RNA polymerase I associated factor PAF53 demonstrates it is essential for cell growth and allows for the analysis of functional domains

Rachel McNamar, Zakaria Abu-Adas, Katrina N. Rothblum…·Lawrence Ian Rothblum

The paper demonstrates that PAF53 is essential for mammalian rDNA transcription and mitotic growth, and identifies functional domains within the protein.

15 citations

yeasthuman

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