Zhenjie Jin

This paper identifies histone modification-associated nucleosome positions in cfDNA that correlate with tumor fraction and cancer state across multiple cancers.

This study identifies genetic and transcriptomic factors associated with severe coccidioidomycosis, finding a founder variant in NLRX1 linked to African ancestry and increased disease risk.

This study investigates how transcription factor subtypes in small cell lung cancer influence response and resistance to DLL3-targeted therapy, revealing subtype-specific mechanisms of resistance.

APEX infers cancer gene expression from plasma cfChIP-seq data, outperforming existing methods and enabling subtype classification and biomarker identification.

SNAP improves classification performance for cell-free chromatin data while maintaining data retention through optimized quality filters and modular design.

The paper identifies cell-free chromatin QTLs (cfcQTLs) from cancer patients' blood to uncover regulatory effects of genetic variants across diverse tissues and diseases.