ImmunologybioRxivPreprint
C1q-mediated steric hindrance limits FcγR contribution to antibody-driven phagocytosis by human neutrophils
Max L.B. Grönloh, Lisanne de Vor, Seline A. Zwarthoff…·Suzan H. M. Rooijakkers
This study shows that complement proteins like C1q block FcγR engagement with IgG, reducing their role in neutrophil phagocytosis, while complement receptors still enhance bacterial clearance.
DOI 10.64898/2026.09.30.755584