Developmental BiologybioRxivPreprint
Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation
Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau…·Matthew G. Vander Heiden
This study shows that increased PHGDH expression in mice leads to premature melanin accumulation in hair follicles, suggesting a role for PHGDH in melanocyte biology and potential involvement in melanoma.
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