Mark R. Sullivan

This study identifies an ABC-F protein in Mycobacterium abscessus that confers resistance to linezolid and other ribosome-targeting antibiotics.

The paper develops an orally effective biotin inhibitor, C48, against Mycobacterium tuberculosis, demonstrating in vivo efficacy in a low-biotin mouse model.

The paper identifies membrane permeability and efflux pumps as key mechanisms of intrinsic antibiotic resistance in Mycobacterium abscessus and highlights potential targets for improving antibiotic efficacy.

The paper uses deep learning to predict drug accumulation in Mycobacterium abscessus, finding that chemical properties alone are insufficient and that models trained on experimental data can accurately predict accumulation for diverse compounds.

The paper shows that phylogenetic clustering in Mycobacterium abscessus is linked to reduced mutation rates and DNA repair gene variation, suggesting adaptation rather than transmission as the cause.

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.

This study shows that increased PHGDH expression in mice leads to premature melanin accumulation in hair follicles, suggesting a role for PHGDH in melanocyte biology and potential involvement in melanoma.