Renqi Wu

This study shows that deleting tyrosine hydroxylase in Ntsr1 neurons reduces diet-induced weight gain without increasing energy expenditure or activity.

The paper develops a knock-in Ntsr1-Flp mouse line for intersectional targeting of midbrain dopamine circuits and demonstrates its utility in distinguishing dopaminergic and non-dopaminergic neurons.

The paper identifies a specific dopamine neuron population in mice required for anticipatory locomotion during food anticipation, showing genetic dissociation of behavioral components.

The paper shows that proposed GPCR markers for adult dopamine neurons, like Nmur1 and Cckar, lack functional expression and challenge existing atlas assignments.