Molecular BiologybioRxivPreprint
Towards sequential conjugation-assisted laboratory evolution (SCALE) of Cas nucleases
Thomas Swartjes, Kristel Doets, Raymond H.J. Staals, John van der OOST
The paper demonstrates that plasmid conjugation can be used for in vivo laboratory evolution of Cas nucleases by enabling cleaving variants to spread through bacterial cultures.
DOI 10.1101/2024.03.20.585880