Author
Wageningen University & ResearchORCID 0000-0001-7528-5483Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Mateusz Walter, Giada Finocchio, Seraina Oberli…·Irma Querques
This study investigates the mechanism of transposon excision by type I-F CRISPR-associated transposases using structural and biochemical analyses.
Thomas Swartjes, Kristel Doets, Raymond H.J. Staals, John van der OOST
The paper demonstrates that plasmid conjugation can be used for in vivo laboratory evolution of Cas nucleases by enabling cleaving variants to spread through bacterial cultures.
Thomas Swartjes, Peng Shang, Dennis T.M. van den Berg…·Richard A. Notebaart
This study shows DNA oligonucleotides can inhibit Cas9 activity in human cells and in vitro by targeting the guide RNA and requiring a PAM-loop for effective inhibition.