Author

Hong B Nguyen

University of DelawareORCID 0009-0009-4331-0993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alekhya Puttagunta· 1 shared Eleftherios Terry PapoutsakisiD· 1 shared Kelvin H. LeeiD· 1 shared Nikola G. MalinoviD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperCell Biology

Alekhya Puttagunta

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1 paper

Recent·Most cited

Late-Stage Large Extracellular Vesicles Reprogram CHO Cell Metabolism in a Glutamine-Dependent Mode and Promote Antibody-Productivity to Cell-Growth Tradeoff

Hong B Nguyen, Nikola G. Malinov, Alekhya Puttagunta, Kelvin H. Lee, Eleftherios Terry Papoutsakis

This study shows that late-stage large extracellular vesicles (LgEVs) from CHO cells reduce growth but increase antibody productivity, with glutamine modulating these effects through metabolic and miRNA mechanisms.

bioRxiv · Jun 29, 2026 · PreprintCell Biology