Author

Kelvin H. Lee

Delaware Biotechnology InstituteORCID 0000-0003-0908-2981Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Eleftherios Terry PapoutsakisiD· 2 shared Alekhya Puttagunta· 1 shared Hong B NguyeniD· 1 shared Jayanth Venkatarama ReddyiD· 1 shared Marianthi IerapetritouiD· 1 shared Nikola G. MalinoviD· 1 shared Sumit Kumar SinghiD· 1 shared Thomas M Leibiger· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Eleftherios Terry PapoutsakisORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 29, 2026

Late-Stage Large Extracellular Vesicles Reprogram CHO Cell Metabolism in a Glutamine-Dependent Mode and Promote Antibody-Productivity to Cell-Growth Tradeoff

Hong B Nguyen, Nikola G. Malinov, Alekhya Puttagunta…·Eleftherios Terry Papoutsakis

This study shows that late-stage large extracellular vesicles (LgEVs) from CHO cells reduce growth but increase antibody productivity, with glutamine modulating these effects through metabolic and miRNA mechanisms.

DOI 10.64898/2026.06.28.735077

mousebulk RNA-seq

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BioengineeringMetabolic EngineeringPeer-reviewedAug 2, 2024

Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese Hamster Ovary (CHO) cell metabolism and N-linked glycosylation in the Fab and Fc regions of the produced IgG

Jayanth Venkatarama Reddy, Sumit Kumar Singh, Thomas M Leibiger…·Eleftherios Terry Papoutsakis

This study examines how bioreactor pH affects CHO cell metabolism and N-linked glycosylation of IgG antibodies using flux balance analysis and glycopeptide mapping.

18 citations

mouseproteomics

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