Samantha K. Bartholomew

This study shows that inhibiting Dyrk1a with the compound DYR533 reduces tau pathology, neuroinflammation, and amyloidosis in mouse models of neurodegenerative diseases.

This study shows that adult choline supplementation in a Down syndrome mouse model improves cognitive flexibility, reduces weight gain, and decreases inflammation and glucose metabolism issues.

This study shows that dietary choline deficiency in AD model mice leads to organ pathology and worsens Alzheimer's disease hallmarks.