Ramón Velázquez

Dyrk1a inhibition with the Novel Compound DYR533: A Cross-Disease Therapeutic Strategy Targeting Amyloidosis, Tau Pathogenesis, and Neuroinflammation

This study shows that inhibiting Dyrk1a with the compound DYR533 reduces tau pathology, neuroinflammation, and amyloidosis in mouse models of neurodegenerative diseases.

Adult choline supplementation in a Down syndrome model reduces co-morbidities and improves cognition

This study shows that adult choline supplementation in a Down syndrome mouse model improves cognitive flexibility, reduces weight gain, and decreases inflammation and glucose metabolism issues.

Reduced PIN1 gene expression in neocortical and limbic brain regions in female Alzheimer's patients correlates with cognitive and neuropathological phenotypes

The paper finds reduced PIN1 gene expression in female Alzheimer's patients correlates with cognitive decline and neuropathological features, suggesting it as a potential biomarker for AD risk in women.

Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimers disease hallmarks

This study shows that dietary choline deficiency in AD model mice leads to organ pathology and worsens Alzheimer's disease hallmarks.