Kristy C. Yuan

This study shows that sodium butyrate improves symptoms of SCA3 by enhancing autophagy through PKA/AMPK signaling in both cell and zebrafish models.

This study uses flow cytometry to detect and quantify protein aggregates in SCA3 models, showing early aggregation before movement impairment and responsiveness to autophagy modulators.

The paper shows sodium valproate activates the sirtuin pathway, improving movement in a zebrafish model of spinocerebellar ataxia-3.