Author

Madelaine C. Tym

Macquarie University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:zebrafish· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Angela S. LairdiD· 2 shared Katherine J. RobinsoniD· 2 shared Kristy C. YuaniD· 2 shared Maxinne WatchoniD· 2 shared Alana De LucaiD· 1 shared Albert LeeiD· 1 shared Alison L. HoganiD· 1 shared Emily K. DoniD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Angela S. LairdORCID

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2 papers

Recent·Most cited

Flow cytometry allows rapid detection of protein aggregates in cell culture and zebrafish models of spinocerebellar ataxia-3

Katherine J. Robinson, Madelaine C. Tym, Alison L. Hogan, Maxinne Watchon, Kristy C. Yuan, Stuart K. Plenderleith, Emily K. Don, Angela S. Laird

This study uses flow cytometry to detect and quantify protein aggregates in SCA3 models, showing early aggregation before movement impairment and responsiveness to autophagy modulators.

Disease Models & Mechanisms · Sep 2, 2021Peer-reviewedNeuroscience

Sodium valproate increases activity of the sirtuin pathway resulting in beneficialeffects for spinocerebellar ataxia-3 in vivo

Maxinne Watchon, Luan Luu, Katherine J. Robinson, Kristy C. Yuan, Alana De Luca, Hannah J. Suddull, Madelaine C. Tym, Gilles J. Guillemin, Nicholas James Cole, Garth A. Nicholson, Roger S. Chung, Albert Lee, Angela S. Laird

The paper shows sodium valproate activates the sirtuin pathway, improving movement in a zebrafish model of spinocerebellar ataxia-3.

Molecular Brain · Aug 20, 2021Peer-reviewedNeuroscience