Emily K. Don

This study uses zebrafish models to show that human TDP-43 overexpression in motor neurons causes MND-like phenotypes through gain-of-function mechanisms, with distinct effects based on TDP-43 variant.

This study shows that sodium butyrate improves symptoms of SCA3 by enhancing autophagy through PKA/AMPK signaling in both cell and zebrafish models.

This study shows that SUMO modification affects TDP-43 phase separation and aggregation in zebrafish spinal neurons, linking post-translational changes to ALS pathology.

This study uses flow cytometry to detect and quantify protein aggregates in SCA3 models, showing early aggregation before movement impairment and responsiveness to autophagy modulators.

This study identifies two phases of cellular regeneration after spinal cord injury in zebrafish, highlighting the role of precursor neuron migration in initiating functional recovery.

The paper validates and optimizes Bimolecular Fluorescence Complementation (BiFC) in zebrafish to study ALS-linked protein aggregate formation in vivo.