Fanni Farkas

The paper investigates how two autism-associated mutations in the Homer1 EVH1 domain affect its internal dynamics and binding properties using experimental and computational methods.

The paper shows that a hexameric complex of GKAP and LC8 proteins has constrained stoichiometry with retained flexibility in the linker region.

This study presents an atomistic model of full-length Homer1 tetramer and NMR structure of its EVH1 domain, revealing ligand-induced conformational changes and dynamic regions in the coiled coil.