Zsófia E. Kálmán

The paper investigates how two autism-associated mutations in the Homer1 EVH1 domain affect its internal dynamics and binding properties using experimental and computational methods.

SLiMMine predicts short linear motifs in the human proteome with high reliability, reducing false positives and discovering novel motifs.

The paper defines the binding preference of tandem SH3 domains in p47phox-related proteins and identifies potential new instances through integrative analysis and structure prediction.

The paper shows that a hexameric complex of GKAP and LC8 proteins has constrained stoichiometry with retained flexibility in the linker region.

The paper investigates how missense mutations in Shank1 PDZ domain affect ligand-specific binding affinity through dynamic interactions.

This study presents an atomistic model of full-length Homer1 tetramer and NMR structure of its EVH1 domain, revealing ligand-induced conformational changes and dynamic regions in the coiled coil.

LeishMANIAdb compiles experimental and predicted Leishmania secretomes and host-pathogen interactions to aid in understanding virulence mechanisms and identifying therapeutic targets.

PSINDB compiles postsynaptic protein-protein interactions with structural and biological details, providing a resource for neurobiology research.

This study develops a pipeline to analyze the cistrome of human postsynaptic density using ChIP-seq data and transcription factor information, finding correlations between co-regulation and protein complex formation.

The paper analyzes disease-causing germline mutations in coiled-coil structures and finds that N-terminal residues are critical for superhelix assembly and folding.