The paper estimates heritability for height and BMI using whole-genome sequence data and finds that rare variants contribute significantly to the missing heritability.

515 citationstop 1%

humanwhole-genome sequencing

𝕏 PostBluesky

GeneticsNature GeneticsPeer-reviewedNov 1, 2019

GWAS of 19,629 individuals identifies novel genetic variants for regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits

Bingxin Zhao, Tianyou Luo, Tengfei Li…·Hongtu Zhu B

This study identifies 287 novel genetic variants associated with brain volumes using GWAS in 19,629 UK Biobank participants and finds genetic correlations with cognitive and mental health traits.

295 citationstop 1%

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsbioRxivPreprintMar 24, 2019

Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n=17,706)

Bingxin Zhao, Jingwen Zhang, Joseph G. Ibrahim…·Hongtu Zhu B

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsCerebral CortexPeer-reviewedJul 2, 2018

Heritability of regional brain volumes in large-scale neuroimaging and genetic studies

Bingxin Zhao, Joseph G. Ibrahim, Yun Li…·John Hsiao

The paper examines the heritability of regional brain volumes using genetic and neuroimaging data from multiple cohorts, finding high heritability and consistent patterns across populations.

58 citations

humanimaging

𝕏 PostBluesky